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Inhibitory Effects of Pueraria Mirifica Aqueous Extracts on 5α-reductase and Prostate Histomorphometry in Testosterone induced Benign Prostatic Hyperplasia Sprague Dawley Rats.
The tuberous root of P. mirifica contains a high number of potent phytoestrogens, including isoflavones (daidzein, daidzin, genistein, genistin, and puerarin), lignans, and coumestans [18]. Traditionally, P. mirifica has been consumed for various purposes, such as an anti-wrinkle agent, appetite promoter, hair-blackening agent, memory enhancer, and longevity booster [19,20]. It exerts an oestrogenic effect on hormone-sensitive tissues and organs, contributing to its antioxidant properties [17], prevention of bone loss [21,22], and prevention of breast cancer in rats [23]. Moreover, studies have demonstrated its ability to downregulate the expression of interleukin-6, androgen receptor, and estrogen receptors in prostatic tissue, leading to anti-inflammatory effects that ameliorate BPH [24]. As BPH is primarily driven by the growth of prostatic tissue in response to the presence of androgens, particularly DHT, which bind to and activate the androgen receptor in the prostate gland, we hypothesize that P. mirifica exhibits inhibitory effects on 5α-reductase. This, in turn, will result in reduced dihydrotestosterone (DHT) production and decreased proliferation of prostatic epithelial and stromal cells, leading to mitigation of benign prostatic hyperplasia (BPH) development in the testosterone-induced BPH rat model. Therefore, the objective of the current study is to evaluate the inhibitory effect of 5α-reductase by P. mirifica and its histomorphological effects in a rat model of testosterone-induced BPH. https://medic.upm.edu.my/upload/dokumen/2023100415534932_2023-0113.pdf
We highly recommend purchasing our Godiva TF Booster pills when using our creams, taking our Bountiful Breast pills and or our Transfemme pills, or taking both for optimum results!
Mohamad J, Masrudin SS, Alias Z, Muhamad NA. The effects of Pueraria mirifica extract, diadzein, and genistein in testosterone-induced prostate hyperplasia in male Sprague Dawley rats. Mol Biol Rep. 2019 Apr;46(2):1855-1871. doi: 10.1007/s11033-019-04638-5. Epub 2019 Feb 1. PMID: 30710233. https://pubmed.ncbi.nlm.nih.gov/30710233/
